課程資訊
課程名稱
博士專題研究
Seminar 
開課學期
101-2 
授課對象
醫學工程學研究所  
授課教師
謝銘鈞 
課號
Biomed8001 
課程識別碼
548 D0020 
班次
10 
學分
全/半年
半年 
必/選修
選修 
上課時間
 
上課地點
 
備註
本課程中文授課,使用英文教科書。
總人數上限:30人 
Ceiba 課程網頁
http://ceiba.ntu.edu.tw/1012Biomed8001_10 
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課程概述

博士專題研究 

課程目標
無 
課程要求
1.每星期挑選一主題報告與同學進行討論。
2.同學分享每星期實驗進度,並由老師給予改善建議。 
預期每週課後學習時數
 
Office Hours
每週二 17:30~19:30 
指定閱讀
無 
參考書目
無 
評量方式
(僅供參考)
 
No.
項目
百分比
說明
1. 
出席 
50% 
 
2. 
報告 
50% 
 
 
課程進度
週次
日期
單元主題
第1週
02/19  1.Cisplatin Selects for Multidrug-Resistant CD133t Cells in Lung Adenocarcinoma by Activating Notch Signaling 2.Circulation and distribution of gold nanoparticles and induced alterations of tissue morphology at intravenous particle delivery 
第2週
03/01  1. AlgiMatrixTM Based 3D Cell Culture System as an In-Vitro Tumor Model for Anticancer Studies 2.Design and evaluation of micellar nanocarriers for 17aag 
第3週
03/05  1.CD133/Prominin-1-Mediated Autophagy and Glucose Uptake Beneficial for Hepatoma Cell Survival 2.Effects of ligands with different water solubilities on self-assembly and properties of targeted nanoparticles 
第4週
03/12  1.Carbon nanotube bottles for incorporation, release and enhanced cytotoxic effect of cisplatin 2.Surface Polyethylene Glycol Conformation Influences the Protein Corona of Polyethylene Glycol-Modified Single-Walled Carbon Nanotubes:Potential Implications on Biological Performance 
第5週
03/19  1.Combined effects of laser-ICG photothermotherapy and doxorubicin. 2.Multifunctional Nanomedicine Platform for Cancer Specific Delivery of siRNA by Superparamagnetic Iron Oxide Nanoparticles-Dendrimer Complexes  
第6週
03/26  1.A combination of liposomal sunitinib plus liposomal irinotecan and liposome co-loaded with two drugs enhanced antitumor activity in PC12-bearing mouse 2.Induction of humoral and cellular immune responses by antigen-expressing immunostimulatory liposomes 
第7週
04/02  1.A Cell-targeted Photodynamic Nanomedicine Strategy for Head & Neck Cancers 2.A Liposomal System Capable of Generating CO2 Bubbles to Induce Transient Cavitation, Lysosomal Rupturing, and Cell Necrosis 
第8週
04/09  1.Improved quality of life in patients with malignant pleural effusion following videoassisted thoracoscopic talc pleurodesis. Preliminary results 2.Size dependent biodistribution and SPECT imaging of 111In-labeled polymersomes 
第9週
04/16  期中考 
第10週
04/23  日本參訪,暫停一次 
第11週
04/30  1. Monitoring ceramide and sphingosine-1-phosphate levels in cancer cells and
macrophages from tumours treated by photodynamic therapy 2.Multimodal In Vivo Imaging Exposes the Voyage of Nanoparticles in Tumor Microcirculation 
第12週
05/07  1.Thermostable Luciferase from Luciola cruciate for Imaging of Carbon Nanotubes and Carbon Nanotubes Carrying Doxorubicin Using in Vivo Imaging System 2.Cellular uptake of functionalized carbon nanotubes is independent of functional group and cell type 
第13週
05/14  1.SPIO-PICsome: Development of a highly sensitive and stealth-capable MRI nano-agent for tumor detection using SPIO-loaded unilamellar polyion complex vesicles (PICsomes) 2.Phthalocyanine-Aggregated Polymeric Nanoparticles as Tumor-Homing Near-Infrared Absorbers for Photothermal Therapy of Cancer 
第14週
05/21  1.A novel tissue engineered three-dimensional in vitro colorectal 4 cancer model 2.Evaluation of Temperature-Sensitive, Indocyanine Green-Encapsulating Micelles for Noninvasive Near-InfraredTumor Imaging 
第15週
05/28  1.Nanobody-albumin nanoparticles (NANAPs) for the delivery of a multikinase inhibitor 17864 to EGFR overexpressing tumor cells 2.Ligands located within a cholesterol domain enhance gene delivery to the target tissue 
第16週
06/04  1.THE RESPONSE OF SPINAL MICROGLIA TO CHEMOTHERAPYEVOKED PAINFUL PERIPHERAL NEUROPATHIES IS DISTINCT FROMTHAT EVOKED BY TRAUMATIC NERVE INJURIES 2.Real-time visualization of pH-responsive PLGA hollow particles containing a gas-generating agent targeted for acidic organelles for overcoming multi-drug resistance 
第17週
06/11  1.Permanent and Peripheral Embolization: Temperature- Sensitive p( N -Isopropylacrylamide- co -butyl Methylacrylate)Nanogel as a Novel Blood-Vessel-Embolic Material in theInterventional Therapy of Liver Tumors 2.CD44 antibody-targeted liposomal nanoparticles for molecular imaging and therapy of hepatocellular carcinoma 
第18週
06/18  期末考週